TGFBR2 and cutaneous melanoma: Skin melanoma is subdivided into three molecular categories based on gene expression: a proliferation oriented-one, driven by the SOX10–MITF pathway; an invasive one, which enhances the activity of epithelial-mesenchymal transition (EMT) and transforming growth factor-beta receptor 2 (TGFBR2); and an immune-mediated one which modifies the tumoral local environment.