In addition to roles that are in common with ILF3, ILF2 also shows specific functions in tumorigenesis: In 1q21 amplified multiple myeloma, 1q21-driven ILF2 binds to YB1, interacts with the splicing factor U2AF65, and influences transcription of DNA damage response factors [174,175]. The gene discussed is ILF2; the disease is AL amyloidosis.