In particular, miR-155 interacts with PD-1/PD-L1 in B-cell lymphoma and with B7-H3, B7-H4 in CRC [84,126]; miR-145 acts on PD-1/PD-L1 in OC and bladder cancer [96,97], meanwhile, in lung cancer and CRC, this miRNA acts on B7-H3 [124,126]. The gene discussed is CD274; the disease is lung cancer.