The cytokine array results of kidney protein lysates showed that the levels of NGAL and IGFBP-2 in the kidneys of Kdm4c−/− mice were 1.5-fold higher than those of WT mice, which indicated that Kdm4c−/− mice had increased kidney inflammation after AKI compared with wild-type mice. This evidence concerns the gene IGFBP2 and acute kidney injury.