Here, we found that, while type 2 diabetes increased the expression of CLOCK (Figure 3A,B), diabetes also significantly increased the level of mitophagy (Parkin/LC3) (Figure 5F–H), suggesting that Pink1–Parkin and Bnip3 are different mitophagy pathways, and the regulation of CLOCK and BMAL1 on different mitophagy pathways may be specific. The gene discussed is BNIP3; the disease is diabetes mellitus.