Our results showed that diabetes upregulated the expression of CLOCK (p < 0.01; Figure 3A,B) and apoptosis (p < 0.05; Figure 7) and downregulated the expression of OPA1 (p < 0.001, Figure 5A,B), and the expression of CLOCK was negative correlated with the expression of OPA1, suggesting that SIRT3 may be involved in the regulation between CLOCK and OPA1. This evidence concerns the gene SIRT3 and diabetes mellitus.