Here, we found that, while type 2 diabetes increased the expression of CLOCK (Figure 3A,B), diabetes also significantly increased the level of mitophagy (Parkin/LC3) (Figure 5F–H), suggesting that Pink1–Parkin and Bnip3 are different mitophagy pathways, and the regulation of CLOCK and BMAL1 on different mitophagy pathways may be specific. This evidence concerns the gene PRKN and type 2 diabetes mellitus.