These analyses revealed that diabetes significantly reduced the expression of OPA1 (p < 0.001) and Fis1 (p < 0.01) (Figure 5A,B,E) in the liver, suggesting that diabetes impaired mitochondrial dynamics, which is consistent with the abnormal mitochondrial networks and morphology observed in diabetic mice (Figure 4A–C). Here, FIS1 is linked to diabetes mellitus.