Partially in line with these studies, our results showed that, even though Th1, but not Th17 cells from RA patients presented lower levels of TNFR1, the frequencies of TNFR1+ Th1 and TNFR1+ Th17 cells were found to be significantly increased in RA patients compared to healthy controls. The gene discussed is TNFRSF1A; the disease is rheumatoid arthritis.