Semorinemab, a mAb that binds to the N-terminus 6–23aa of all six isoforms of human tau, both monomeric and oligomeric, regardless of phosphorylation status, has recently shown (31 August 2021), results indicating a 43.6% slowing of decline on the ADAS-Cog11 co-primary, which enrolled participants in the moderate stages of AD [121]. Here, MAPT is linked to Alzheimer disease.