MAPT and Alzheimer disease: Currently, the second generation of anti-Tau mAbs is under clinical development including phopho-specific anti-Tau mAbs (i.e., PNT001/NCT04677829 and JNJ-63733657/NCT04619420 that bind to p-Tau231 and p-Tau217, respectively) [124,125], mid-region anti-Tau mAbs (i.e., Bepranemab/ NCT04867616) or early pathological forms of Tau (Zagotenemab/LY3303560 against a pathological form of soluble Tau which forms before the assembly of PHF) are under clinical development in patients with early AD (Figure 2) [126].