A significant number of pro-inflammatory molecules involved in CNS diseases have been identified, such as interleukin 6 (IL-6), tumor necrosis factor (TNFα), and the inflammasome complex (NRLP3) and circulating levels of peripheral cytokines have been shown to correlate to cytokine levels in the brain, AD severity, brain atrophy, and cognitive performance (i.e., TNFα, MCP-1) [131,132,133]. Here, TNF is linked to Alzheimer disease.