Of the known genetic cases, mutations in the C9ORF72, SOD1, TARDBP [2,3,4], NEK1 [5,6], UBQLN2 [7,8], KIF5A [9,10], and FUS [11,12] genes contribute to familial ALS cases [13]. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.