A standardized extract (HVE) (0.5–125 μg/mL) was compared to hamamelitannin (HT), its main compound (0.5–5 μg/mL), in a model of human keratinocytes (HaCaTs), challenged with an AD-like cytokine milieu (TNF-α, IFN-γ, and IL-4). Here, IFNG is linked to Alzheimer disease.