The common allele (T or A, according to the considered strand) of the top single nucleotide polymorphism (SNP) rs1990622, together with those of other SNPs mapping at the same linkage disequilibrium block, have been associated with an increased risk of FTD, especially, but not exclusively, in the presence of TDP-43 pathology (risk allele) [16,19,20,21,22,23]. Here, TARDBP is linked to frontotemporal dementia.