To date, few studies have focused on the impact of TMEM106B on disease susceptibility and genotype-phenotype correlation in ALS cohorts, revealing no association of the rs1990622 SNP with age at onset or death but a doubtful protective role of the minor allele (C or G, according to the considered strand) on cognitive functions [29,30,31,32]. Here, TMEM106B is linked to amyotrophic lateral sclerosis.