Furthermore, we identified CXCL1, CXCL2, and CXCL3 as SASP factors secreted by senescence-induced hPSCs, and the inhibition of the CXCLs/CXCR2 axis attenuated their stimulating effects on the proliferation and migration of pancreatic cancer cells. Here, CXCL1 is linked to familial pancreatic carcinoma.