Among them, we focused on C-X-C motif chemokine ligand (CXCL)-1 (6.1-fold), CXCL2 (2.2-fold), and CXCL3 (6.6-fold) as SASP factors, as they act on the common receptor, C-X-C motif chemokine receptor 2 (CXCR2), and the CXCLs/CXCR2 axis in the tumor–stromal interaction promotes the progression of pancreatic cancer. Here, CXCL2 is linked to neoplasm.