NFKB1 and dementia: The chronic inflammatory damage caused in the brain by type 2 diabetes is so closely associated with the development of dementia that it has been labeled as “type 3” or “brain diabetes.” One of the predominant causes for the rise in these conditions is the HFD, including the Western diet (WD), which stimulates the inflammatory response mediated by NF-κB and its associated cytokines and the oxidative stress and an increase in the production of reactive oxidative species.