The application of Resolvin D1 to impair cancer-associated fibroblasts (CAFs)-derived COMP by targeting FPR2/ROS/FOXM1 signaling, thereby inhibiting the promotion of CAFs on the growth and metastasis of HCC tumors, has demonstrated that targeted matrix-derived COMP may be an effective strategy for blocking tumor-matrix interaction [99]. The gene discussed is COMP; the disease is hepatocellular carcinoma.