MR expression is increased during human pulmonary arterial hypertension in humans, and finerenone was found to impair remodeling in the vasculature and pulmonary hypertension via MR blockade through the minimization of the buildup of pulmonary artery SMCs in monocrotaline and Sugen/Hypoxia rat models of pulmonary arterial hypertension [106]. The gene discussed is NR3C2; the disease is pulmonary hypertension.