NR3C2 and glomerulosclerosis: In the kidneys, MR overactivation can result in fibrosis, glomerulosclerosis, a decline in glomerular filtration rate (GFR), proteinuria, and tubulointerstitial damage [1,14], whereas MR overactivation in the heart can cause myocardial hypertrophy, fibrosis, inflammation, and oxidative stress [15].