Finerenone also increased the mRNA expression of molecules involved in thermogenesis such as uncoupling protein-1 (UCP-1), peroxisome proliferator-activated receptor-γ (PPAR-γ) coactivator 1 alpha, and beta-3 adrenoreceptor in brown adipose tissue, suggesting that finerenone may be a promising pharmacologic agent to treat human metabolic diseases associated with adipose tissue dysfunctions [110] (Table 3). The gene discussed is UCP1; the disease is metabolic disease.