IH exposure affected the phosphorylation and activation of ERK, JNK, and p38 kinases the same as by downregulation in the Dp group compared to controls (Figure 4B–D), whereas the p-MEK/MEK was slightly higher (104 ± 5%, p = 0.027) after 3 days of IH in comparison with the CTL + IH group (68 ± 16%) (Figure 4E). Here, MAPK8 is linked to isolated hemihyperplasia.