Genetic mutations in superoxide dismutase 1 (SOD1, chromosome 21), C9orf72 (chromosome 9), heterogeneous nuclear ribonucleoprotein P2 (FUS, chromosome 16), NIMA related kinase 1 (NEK1, chromosome 4), Ubiquilin-2 (UBQLN2, chromosome X), kinesin family member 5A (KIF5A, chromosome 12), and TAR-DNA binding protein 43 (TDP43, chromosome 1) lead to familial ALS onset [51,52,53]. This evidence concerns the gene NEK1 and amyotrophic lateral sclerosis.