Similarly, GYY-4137 has been shown to inhibit lipopolysacharid-evoked release of pro-inflammatory mediators from macrophages or IL-8 secretion and to decrease cell proliferation in airway smooth muscle cells exposed to fetal calf serum growth factor as well as to stimulate the synthesis of the anti-inflammatory chemokine IL-10 in rat plasma during sepsis [43]. This evidence concerns the gene CXCL8 and Sepsis.