Angiotensin II (Ang II) is also suggested to be associated with fructose-induced hypertension, not only through its vasoconstrictor feature, but it is known to stimulate the generation of reactive oxygen species (ROS) (including superoxide and hydrogen peroxide) [23] and it is able to up-regulate matrix metalloproteinases (MMPs) [24]. The gene discussed is AGT; the disease is hypertensive disorder.