GYY-4137 was also supposed to protect against myocardial fibrosis in SHR [11], which may be related to the inhibition of oxidative stress, the blockage of transforming growth factor β1 (TGF-β1)/Smad2 signaling pathway, and the decrease in the expression of α-smooth muscle actin in cardiac fibroblasts. This evidence concerns the gene SMAD2 and Myocardial fibrosis.