The epipharynx is a physiologically immunoactive site, which serves as a source of antigen-specific IgA-producing B cells responsible for protective mucosal immunity [19,20], but hyperinflammation of the epipharynx is associated with not only local symptoms, but also the development of intractable systemic diseases such as IgA nephropathy (IgAN), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and Long COVID [5,6,7,21]. The gene discussed is CD79A; the disease is IgA glomerulonephritis.