AKT1 and diffuse large B-cell lymphoma: Bhalla et al. [85] reported that a panhistone deacetylase inhibitor, PCI-24781, induced autophagy in diffuse large B-cell lymphoma (DLBCL) cells through hypoxia-inducible factor 1α (HIF-1α) and that this effect was mediated by the PI3K/AKT/mTOR pathway.