This review can not only solve the early noninvasive diagnostic indicators and clinical future targets so as to provide a certain reference basis, but also sheds light on the molecular mechanism by means of macro and micro clear concrete mechanisms and the effect of the mTOR NAFLD, summed up in the form of a table (Table 1), and mTOR signaling pathways/mechanism of NAFLD stages and the influence of the development process. The gene discussed is MTOR; the disease is metabolic dysfunction-associated steatotic liver disease.