According to the table (Table 1) and the above explanation, we can also find that there are many factors affecting the development of NAFLD, but most of them focus on the signaling pathways such as PI3K/AKT/mTOR, AMPK/mTORC1, and mTORC1/SREBP1c/DNL, which directly or indirectly affect the lipid accumulation and mediate the level of autophagy in the liver. This evidence concerns the gene MTOR and metabolic dysfunction-associated steatotic liver disease.