The mTORC1 complex subunit, Raptor, has been shown to specifically block the lipid origin of insulin Akt signaling at pleckstrin homology domain leucine-rich repeat-containing protein phosphatase 2 (PLHPP2), which targets Akt at Ser473, thereby blocking the progression of NAFLD. The gene discussed is INS; the disease is metabolic dysfunction-associated steatotic liver disease.