FOXO1 and metabolic syndrome: Therefore, data have shown that NAFLD is driven by metabolic syndrome and is closely related to lipid metabolism [via sterol regulatory element-binding proteins (SREBPs) [8], IR {via forkhead box O1 (Foxo1) and phosphatidate phosphatase 1 (Lipin-1)}, {OS via p53-induced gene 3 (PIG3), p53, c-Jun N-terminal kinase (JNK)}, the intestinal flora {via toll-like receptor (TLRs)}, autophagy, inflammation, genetic polymorphisms, and epigenetics [9,10].