To test this hypothesis, LPS-induced macrophage models of liver autophagy and NASH were treated with scoparone, which suppressed the ROS/p38/Nrf2 axis and the PI3K/AKT/mTOR pathway and enhanced autophagic flux by coregulating autophagy and inhibiting inflammation [103]. This evidence concerns the gene MTOR and metabolic dysfunction-associated steatohepatitis.