In addition, Yes-associated protein (YAP) [104], which is closely associated with mTOR, was reported to play a key role in the progression of NASH through the production of pro-inflammatory cytokines and the persistence of liver inflammation, providing insights into the mechanism of LPS-mediated inflammation in NAFLD progression through the LPS/TLR4 signaling pathway [105]. This evidence concerns the gene TLR4 and metabolic dysfunction-associated steatohepatitis.