MOG and systemic lupus erythematosus: It was demonstrated that immunization of systemic lupus erythematosus (SLE)-prone MRL-lpr/lpr mice with DNA–protein complexes [15,16,17] as well as C57BL/6 mice with DNA–histone complexes and MOG [11,12,13,14] results in an acceleration of SLE and EAE development.