In addition, compared to the lowest IL-6 levels, the highest levels were linked to a more than twofold greater risk for HF hospitalization and correlated with negative outcomes independently of recognized risk predictors and biomarkers (hs-CRP, highly sensitive troponin I (hs-TnI) and brain natriuretic peptide (BNP)). The gene discussed is NPPB; the disease is hydrops fetalis.