Wolsk et al. demonstrated that, in patients with recent ACS associated with type 2 diabetes mellitus (which is known to interfere with values of BNP, regardless of the presence of a cardiovascular comorbidity), BNP along with NT-proBNP were great predictors not only for heart failure (p < 0.001) and death (p < 0.001) but also for stroke and myocardial infarction [47]. This evidence concerns the gene NPPB and diabetes mellitus.