The secondary analysis biomarker sub-study in the Platelet Inhibition in Patient Outcomes (PLATO) study found a substantial correlation between NT-proBNP levels and all-cause death after an ACS (HR: 2.96), as well as death secondary to HF (HR: 8.20), arrythmia (HR: 3.89) and sudden cardiac death. The gene discussed is NPPB; the disease is cardiac arrhythmia.