There was a significant difference in renin concentration between sepsis and septic shock patients on the first (45.8 and 103.4 pg/mL, respectively) and third (24.7 and 102.1 pg/mL, respectively) days, but not on the fifth day (18.9 and 58.6 pg/mL, respectively) (Figure 4). The gene discussed is REN; the disease is Sepsis.