Herein, tumor growth between HFD-fed obese and ND-fed lean mice was closely related to elevated circulating WBCs, lymphocytes, neutrophils, plasma levels of soluble P-selectin, TGF-β1 and HMGB1, as well as increased tumor expressions of HMGB1, RAGE, Smad2/3 phosphorylation, CD62P and MPO. The gene discussed is SMAD2; the disease is neoplasm.