In summary, integrative analysis of the data of our study indicates that the basal expression of a gene signature enriched in B-cell-related genes and the presence of intra-tumoral Plasma cells with high expression of IGKC can predict the promotion of the anti-tumor immune response in the PD1 blockade scenario in melanoma patients with greater potential than the reference prediction algorithm. The gene discussed is IGKC; the disease is melanoma.