In concordance with the RNA-sequencing expression levels, the genes involved in the response mechanisms linked to the immune system, and in particular the B-cell signature, (TNFRSF11B, IGLV6-57, IGHA1), were highly expressed in good responders, while the genes related to tumor-associated mechanisms of response (GRIA1), were highly expressed in bad responders (Figure S1a). This evidence concerns the gene TNFRSF11B and neoplasm.