Our study showed that tSUVmean only among semiquantitative parameters, tSkewness and tKurtosis as first order radiomic features were predictors of DRE results, while none of the semiquantitative parameters were able to be significantly correlated to the main clinical/histological parameters in PC patients, such as low/high PSA values and low and high-risk GS in PC patients referring 18F-FECh PET/CT for primary staging. This evidence concerns the gene KLK3 and pachyonychia congenita.