Given the strict interplay between IRE1α/XBP1 and c-Myc, previously demonstrated by us and others [7,19], and the key role of c-Myc in BL growth/survival, we next investigated whether the higher cytotoxic effect of 4μ8C observed in Akata and Oma 5 could correlate with a stronger downregulation of c-Myc in these cells compared to BL36. The gene discussed is XBP1; the disease is Burkitt lymphoma.