It has been reported that IRE1α/XBP1 signaling is particularly important for growth/survival of Myc-overexpressing BL cells, dependent on elevated stearoyl-CoA-desaturase 1 (SCD1) activity, and that the inhibition of IRE1α/XBP1 could potentiate the cytotoxicity of chemotherapies already used against BL [8]. The gene discussed is XBP1; the disease is Burkitt lymphoma.