AKT1 and myocardial infarction: Furthermore, in rats and mice with myocardial infarction allicin modulated the gene expression programs associated with the activation of signaling pathways involved in cell death and apoptosis by up-regulating the expression of eNOS, Bcl-2, phosphorylated phosphoinositide 3-kinase (p-PI3K), and phosphorylated protein kinase B (p-Akt) [77,79].