RNASET2 and cancer: Early studies of the T2 ribonuclease from Aspergillus niger (ACTIBIND) showed the ability of this molecule to bind cytoplasmic actin and interfere with the intracellular network in human cells and to significantly decrease in vitro colony formation in several human cancer cell lines, including ovarian A2780 and breast ZR-75-1 cancer cell lines [22].