RNASET2 and cancer: These data deals with the identification of RNASET2 alarmin molecule, according with the proposed model that cells from early-stage neoplastic lesions undergoing cancer-related stressful conditions (such as hypoxia or nutrient starvation), actively increase RNASET2 protein expression and secretion in the TME, where it acts as a M1-polarizing agent for resident tissue macrophages and/or recruited circulating monocytes.