PTEN and ovarian carcinoma: Moreover, using GeneMANIA web-based database software, the authors were able to predict gene/protein-gene/protein interactions and found a direct interactions of RNASET2 with several genes or proteins involved in drug resistance in ovarian cancer, such as checkpoint kinase 2 (CHEK2), programmed cell death 4 (PDCD4), phosphatase and tensin homolog (PTEN), split hand/foot malformation (ectrodactyly) type 1 (SHFM1) and Yes-associated protein 1 (YAP1) [57].