RNASET2 and cancer: The functional consequences of such marked modulation of the cell cytoskeleton were also investigated and as expected, both cell migration and extracellular matrix (ECM)-adhesion pattern were found to be significantly increased in RNASET2-KD cells, thus including another key feature of human cancer cells (i.e., their migration and ECM adhesion rate) among those negatively regulated by the human RNASET2 protein.