Moreover, subsequent in vitro assays using a recombinant RNASET2 protein unveiled its ability to act as a powerful chemotactic agent for peripheral blood leukocytes (PBL)-derived human macrophages, thus providing a further validation of the role played by macrophages in RNASET2-mediated tumor suppression in vivo [45]. The gene discussed is RNASET2; the disease is neoplasm.