Briefly, Rg3 repressed the cancer stemness in both colorectal cancer (LoVo, SW620, HCT116) and liver cancer cells (HepG2, MHCC-97L) via reductions in CD24, CD44, and the epithelial cell adhesion molecule (EpCAM) and activation of ARHGAP9, a tumor suppressor gene. This evidence concerns the gene ARHGAP9 and cancer.