To further determine whether overexpression of FAK has any effect on learning and memory in 3xTg-AD mice, the fear conditioning paradigm was performed on mice that were stereotaxically injected into their hippocampus with a lentiviral vector expressing the Ptk2 gene (FAK-OE) or a control virus (Figure 2A–C). The gene discussed is PTK2; the disease is Alzheimer disease.