Interestingly, the angiotensin-converting enzyme (ACE) gene, which is also a key component in the renin–angiotensin system, was widely reported to be associated with psoriasis [89,90,91,92,93,94], further supporting the involvement of the renin–angiotensin system in the development of psoriasis and its related hypertension. The gene discussed is REN; the disease is psoriasis.