Furthermore, it should not be excluded that Piezo1 microinjury could evolve into Piezo2 microinjury gradually in osteoporosis, as is suggested in the paradox continuum of initially pain-free dry eye disease into neuropathic corneal pain [5], not to mention that the “leakiness” to subthreshold-imbalanced Piezo Ca2+ currents due to these Piezo microinjuries could explain the “calcium stealing” from bones for years before pain evolves due to fractures [1]. Here, PIEZO2 is linked to osteoporosis.