TRPM8 and pancreatic neoplasm: Consistent with the GEPIA results, the expression levels of TRPA1, TRPM8, TCAF1, and TCAF2 were significantly higher in pancreatic cancer tissue (p < 0.001), and TRPV6 expression was significantly lower in pancreatic cancer tissue compared to normal tissues (p < 0.001) (Figure 1B).