In conclusion, actual data concerning the association between vitamin D, VDR, and HCC, in addition to attempting to explain the mechanisms related to the role of vitamin D in HCC, from a pathogenetic and therapeutic point of view, could open new horizons on the role of hormones in hepatocarcinogenesis, and also to associate vitamin D analogues with standard therapy for HCC. The gene discussed is VDR; the disease is hepatocellular carcinoma.