TNF and neoplasm: The aggressiveness of TNBC is gained by the surrounding tumor microenvironment (TME); several pro-inflammatory mediators, including tumor necrosis factor (TNFs), interferons (IFN), interleukins (IL), and chemokines (CXC/CCL) have been shown to participate in tumorigenesis, even though their pleiotropic roles in biological processes remain unclear [4].