APP and Alzheimer disease: Heneka et al. have found that AD mice with a double knockout of Nlrp3 or Casp1 (APP/PS1/NLRP3−/− and APP/PS1/Casp-1−/−) demonstrate improved memory function, as well as decreased levels of caspase-1, Il-1β, and Aβ deposits compared to APP/PS1 mice.