IFNG and chronic obstructive pulmonary disease: Collectively, these observations suggest that IFNγ, previously thought to be protective in asthma [107], could be pathogenic in a specific population of asthma (T2-low, chronic, severe) and COPD (with acute exacerbations) patients and can contribute to the poor GC responsiveness seen in these patients [101,102,108] (Figure 2).