Our results in MES-like hypoxia-dependent GBM cells show that both the hypoxia-induced HIF-1α expression (Figure 6A) and the upregulation of NBCe1 activity (Figure 6D) were prevented in the presence of acidosis, suggesting NBCe1 regulation in an HIF-1α-dependent manner. Here, SLC4A4 is linked to glioblastoma.