Taking into consideration that acidic pH and tumour hypoxia negatively regulate mTORC1 [32] together with the observation that mTOR-mediated phosphorylation of NBCe1 at S255–257 enhances NBCe1 activity [14], the acidosis-induced decreased NBC activity might be attributed to post-translational modifications of NBCe1. This evidence concerns the gene SLC4A4 and neoplasm.