The different antibodies investigated in APS (LA, aCL, anti-β2GPI, anti-prothrombin (anti-PT), anti-phosphatidylserine/prothrombin (anti-PS/PT), and anti-phosphatidylethanolamine) can be evaluated for specificity of phospholipid surface inhibition. This evidence concerns the gene PRB2 and autoimmune polyendocrinopathy.