Excessive salt consumption/salt sensitivity, hypertension, and obesity are CVD risk factors associated with the excessive activation of vascular MR signaling that causes vascular inflammation, oxidative stress, remodeling, and fibrosis, leading to vascular insulin resistance, vascular stiffening, impaired vascular relaxation, and hypertension. This evidence concerns the gene NR3C2 and obesity due to melanocortin 4 receptor deficiency.