Studies have also reported that adipose tissue MR-mediated activation of the mammalian target of the rapamycin (mTOR)/ribosomal S6 kinase (S6K1) signaling pathway further activates PPARs and C/EBP signaling to promote adipogenesis in diet-induced obesity [1]. The gene discussed is MTOR; the disease is obesity due to melanocortin 4 receptor deficiency.