Considering the endothelial dysfunction induced by this model, this result may appear surprising, indeed, endothelial dysfunction is also associated with the activation of endothelial cells that become pro-inflammatory, increasing the expression of adhesion molecules, producing monocyte chemoattractant protein-1 (MCP-1), increasing leukocyte transmigration and activation, and involving cytokines [21]. Here, CCL2 is linked to endothelial dysfunction.