In particular, surfactin in the in vivo model of melanoma skin cancer and the B16F10 melanoma cell line [45] led not only to an increase in tumor infiltration by mast cells, but also to an increase in intratumoral histamine levels, levels of IgE, interferon gamma, interleukins (IL)-2, IL-6, IL-12, as well as tumor necrosis factor-α in serum. This evidence concerns the gene IGHE and melanoma.