SOD1 and type 2 diabetes mellitus: Our results showed that the activity of SOD was significantly decreased by 87% in the epididymal tissue of rats from the T2DM group (4628 ± 545.90 U/mg of protein), compared to the animals of the control group (36,535 ± 13,554 U/mg of protein) (SP = 100%) (Figure 4b).