We found a significant decrease (by 22%) in the expression of the SIRT1 in the epididymal tissue of the T2DM group animals (0.78 ± 0.12-fold variation to control) when compared with control group rats (1.00 ± 0.09-fold variation) (SP = 86%) (Figure 2). Here, SIRT1 is linked to type 2 diabetes mellitus.