Finally, it has been found that in Her-2/neu and triple-negative breast cancer (TNBC), there is an increased expression of LRP1 that is linked to neoplastic aggressiveness due to high histological grade, elevated mitotic index, Ki67 > 20% and tumor recurrence, while in endometrial carcinoma (EC), the increased expression of LRP1 is associated with p53 alterations and p16 protein overexpression [45]. The gene discussed is LRP1; the disease is endometrial carcinoma.