LRP1B ligands link the receptor to altered cellular invasion/metastasis and support the correlations observed between LRP1B genetic and epigenetic alterations and many types of cancer [107,108,109], including urothelial malignancies [110], esophageal squamous cell carcinomas [111], gliomas, cervical adenocarcinomas, B-cell lymphomas [112], leukemias [113] and primary pulmonary adenocarcinomas [114]. The gene discussed is LRP1B; the disease is cervical adenocarcinoma.