VLDLR II is overexpressed in lymph node and distant metastasis in gastric and breast cancer patients, promoting cell proliferation and migration.ATRA attenuates proliferation and migration through significant decreases in VLDLR II, while PMA has the opposite effect on VLDLR II, which activates β-catenin/TCF signaling and modulation of MMP-2 and MMP-9. The gene discussed is MMP9; the disease is breast cancer.