The LRP8 regulation of the Wnt/β-Catenin pathway has been observed both in triple-negative breast cancer, where LRP8 depletion inhibits breast cancer stem cells, cell proliferation and invasion and epithelial–mesenchymal transition [9], and in NSLC, in which an increase in LRP8 expression facilitates tumor proliferation [148]. Here, LRP8 is linked to neoplasm.