Some features of LRP8 are, from this point of view, relevant: from one side, the same pathways (for example Wnt) foresee LRP8 as pivotal regulator both in degeneration like Alzheimer’s and in tumor genesis such as in breast cancer; from the other side, ApoE, the most famous ligand of LRP8, is at the crossroads between metastatic proliferation and Alzheimer’s-type neurodegeneration. This evidence concerns the gene LRP8 and neoplasm.