CD274 and osteosarcoma: In osteosarcoma, the overexpression of LRP8 compared with normal tissues, increases phospho-STAT3 (p-STAT3) levels and facilitates its translocation into the nucleus, resulting in an enhancement of mRNA, protein and promoter activity of the programmed death-ligand 1 (PD-L1), which is a marker of metastasis and mortality risk in osteosarcoma [141].