RUNX2 and proximal spinal muscular atrophy: At seven months, OVX associated to deficient diet and methylprednisolone injections revealed a reduction in bone volume/total volume (BV/TV), Tb.Th, OC, (osteoid surface/bone surface) OS/BS, cell density, osterix (Sp7), runt-related transcription factor 2 (Runx2) and spinal muscular atrophy (SMA) in comparison to control animals [27].