The expression change of the following genes was analyzed CD82 (CD82 molecule), CST7 (Cystatin F, leukocystatin), CTSK (Cathepsin K), CTSL (Cathepsin L1), KISS1 (KiSS-1 metastasis-suppressor), METAP2 (Methionyl aminopeptidase 2) and NME4 (Non-metastatic cells 4, protein expressed in) in fibroblasts after treatment with exosomes from ovarian cancer cells. The gene discussed is KISS1; the disease is ovarian cancer.