In HepG2 hepatocellular carcinoma cells, BoA down-regulated the corticosteroid-binding globulin (CBG) gene expression, a marker for GR transrepression, without up-regulating tyrosine aminotransferase (TAT) gene expression, a marker of GRE transactivation (Figure 7). The gene discussed is SERPINA6; the disease is hepatocellular carcinoma.