TGFB1 and neoplasm: As demonstrated by Guo et al. [153], the beneficial effects of GA against liver fibrosis rely on its capacity to upregulate the expression of miR-663a followed by the inhibition of TGF-β/Smad pathway (Figure 10) in HSCs, results also supported by a previous study that indicated miR-663 as a tumor suppressor which acts by regulating the TGF-β1 pathway [156].