MTOR and familial pancreatic carcinoma: The current literature suggests that BA exerts its antiproliferative effect in pancreatic cancer by the induction of mTOR-mediated apoptosis without any influence on autophagy or other apoptotic triggering pathways, such as NRf2 and JAK2, as was shown in vitro in PANC-1 and SW1990 cells and in vivo on a mouse xenograft model.