NFKB1 and myocardial infarction: Upon myocardial infarction treatment, the reperfusion process itself may also lead to irreversible damage to the myocardium, generally termed ischemia/reperfusion injury (I/R); the principal players involved in the development of I/R injury are inflammation and apoptosis, both associated with the TRL4/NF-κB signaling pathway [205,206].