At the moment, the scientific literature agrees that BA’s mechanism of action in rheumatoid arthritis is linked to the inhibition of TNF-α, which further downregulates the Akt/NF-κB pathway, decreases MMPs expression, and reduces the level of pro-inflammatory cytokines including IL-1β, IL-6, IL-8, and IL-17A as well as several growth factors such as VEGF and TGF-β (Figure 5) [52,53,54]. Here, NFKB1 is linked to rheumatoid arthritis.