The main purpose of the present study was to analyze the influence of HNF1α overexpression on NF–κB gene expression and the expression of genes responsive to the activation of the NF–κB signaling pathway, i.e., genes encoding IL-6, VCAM-1, ICAM-1, and MCP-1 in the livers of CRF rats—an experimental model of CKD in humans. Here, VCAM1 is linked to chronic kidney disease.