ACBD3 and cancer: Many roles of ACBD3 could arguably promote the hallmarks of cancer, including dysregulating cellular energetics, sustaining proliferative signaling, replicative immortality, and tumor-promoting inflammation [4,17,29,30,31,32,33]; the location of ACBD3 on arm q of chromosome 1 may also be important, as 1q amplification is common in breast cancer, and the ACBD3 locus (1q42.13) is within a the largest region of gain [34].