Triple-negative breast cancer (TNBC) refers to a type of breast cancer in which the immunohistochemistry of the cancer tissue is negative for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER-2), and it accounts for 15–20% of all breast cancer patients [2]. This evidence concerns the gene ESR1 and triple-negative breast carcinoma.